N-[(5-Chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)carbonyl]-N′-(4-hydroxyphenyl)thiourea
نویسندگان
چکیده
In the title compound, C(18)H(15)ClN(4)O(2)S, the pyrazole ring makes dihedral angles of 67.4 (1) and 12.5 (1)° with the phenyl and 4-hydroxy-phenyl groups, respectively; the two benzene rings are twisted by 60.1 (1)° with respect to each other. The thio-urea NH groups are involved in N-H⋯O and N-H⋯Cl intra-molecular hydrogen bonds. A hydrogen bond between the phenolic OH group and the pyrazole N atom connects mol-ecules into a one-dimensional polymeric structure.
منابع مشابه
Two isomeric reaction products: hydrogen-bonded sheets in methyl 4-(5-amino-3-phenyl-1H-pyrazol-1-yl)-3-nitrobenzoate and hydrogen-bonded chains of edge-fused rings in methyl 3-nitro-4-[(5-phenyl-1H-pyrazol-3-yl)amino]benzoate.
In methyl 4-(5-amino-3-phenyl-1H-pyrazol-1-yl)-3-nitrobenzoate, C(17)H(14)N(4)O(4), the molecules are linked into complex sheets by a combination of N-H...N, N-H...O and C-H...O hydrogen bonds. In the isomeric methyl 3-nitro-4-[(5-phenyl-1H-pyrazol-3-yl)amino]benzoate, molecules exhibit a polarized molecular-electronic structure and are linked into chains of edge-fused rings by a combination of...
متن کاملNon-classical transformation of benzendiazonium hydrogen sulfates. Access to 1,3-dimethylisochromeno[4,3-c]pyrazol-5(1H)-one, a potential benzodiazepine receptor ligand.
The compound 2-((1,3-dimethyl-1H-pyrazol-5-yl)(methyl)carbamoyl)benzene-diazonium hydrogen sulfate (10) was reacted with copper sulfate and sodium chloride, in the presence of ascorbic acid as reducing agent, to afford a mixture of the chlorinated epimers 4'-chloro-2,2',5'-trimethyl-2',4'-dihydrospiro[isoindoline-1,3'-pyrazol]-3-one (18) and (19), the epimers 4'-hydroxy-2,2',5'-trimethyl-2',4'-...
متن کاملN-(5-Chloro-3-methyl-1-phenyl-1H-pyrazol-4-ylcarbonyl)-N′-(2,6-dimethylphenyl)thiourea
In the title compound, C(20)H(19)ClN(4)OS, the pyrazole ring makes dihedral angles of 89.2 (4) and 46.4 (4)° with the phenyl and substituted benzene rings, respectively; these two six-membered rings are twisted by 52.1 (4)° with respect to each other. There are intra-molecular hydrogen bonds of types N-H⋯O and N-H⋯Cl.
متن کامل(E)-4-Chloro-N-[(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene]aniline
In the title compound, C(17)H(13)Cl(2)N(3), the dihedral angle between the pyrazole ring system and 4-chloro-phenyl ring is 26.1 (2)°. The C=N bond linking the two aromatic rings has an E conformation.
متن کاملSynthesis Characterization and Antimicrobial Activity of N- ((5-((6-OXIDO-6-(4 Substituted Phenoxy)-4,8-DIHYDRO-1H- [1,3,2] Dioxaphosphepino [5,6-C]Pyrazol-1-YL) Methyl)- 1,3,4-Thiadiazol-2-YL)Carbamoyl) Substituted Benzene Sulfonamides
New novel derivatives of N-((5-((6-oxido-6-(4 substituted phenoxy)-4,8-dihydro-1H-[1,3,2] dioxaphosphepino [5,6-c]pyrazol-1-yl) methyl)-1,3,4-thiadiazol-2-yl)carbamoyl) substituted benzene sulfo namides (7a-o as depicted in scheme) were Synthesized by condensation reaction of 4substituted Phenyl phosphorodichloridates (6a-c) and N-((5-((4,5-bis(hydroxymethyl)-1H-pyrazol-1-yi)methyl)1,3,4-thiadi...
متن کامل